Overdosage of cholestyramine resin has actually been noted in the patient getting 150% of the most encouraged daily dosage for any duration of several weeks. No unwell outcomes were being documented.
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The utmost proposed every day dose is six packets or scoopfuls of Prevalite® (cholestyramine for oral suspension, USP) powder (24 grams of anhydrous cholestyramine resin). The suggested time of administration is at mealtime but might be modified to stay away from interference with absorption of other medications. Although the encouraged dosing routine is 2 times everyday, Prevalite® (cholestyramine for oral suspension, USP) powder might be administered in 1 to 6 doses every day.
On the other hand, in watch of The point that cholestyramine resin is confined on the GI tract and never absorbed and in light-weight with the animal experiments referred to higher than, a 6-year write-up-demo comply with-up on the LRC-CPPT5 individual inhabitants continues to be done (a total of 13.4 a long time of in-demo in addition article-trial adhere to-up) and revealed no sizeable difference inside the incidence of bring about-particular mortality or most cancers morbidity amongst cholestyramine and placebo handled people.
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Two controlled clinical trials conolidine have examined the effects of cholestyramine monotherapy upon coronary atherosclerotic lesions utilizing coronary arteriography. While in the NHLBI Form II Coronary Intervention Trial2, 116 patients (eighty% male) with coronary artery sickness (CAD) documented by arteriography ended up randomized to cholestyramine resin or placebo for 5 years of cure.
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